Anna Kuzina
Biomedical Machine Learning & Computational Biology

Anna Kuzina

ML developer and molecular immunology researcher with experience in 3D medical imaging, experimental immune profiling, and quantitative biomedical research. I am interested in building robust computational models for complex clinical and biological data.

Anna Kuzina

Research interests

Biomedical machine learning Computational immunology Medical imaging Multimodal biomedical data Robust modeling in small and heterogeneous cohorts

Research experience

ML Developer Intern

2026 — present
Clinic of Urology, Sechenov University · supervised by Ivan Chernenkiy
  • Developed a MONAI/PyTorch pipeline for liver and hepatic lesion segmentation from multiphase CT, covering curation, preprocessing, multiphase input handling, training and evaluation.
  • Investigated the persistent failure to learn the lesion class and jointly reworked the overlapping-label representation, loss and class-aware patch sampling, establishing a trainable lesion baseline.
  • Replaced single-split evaluation with class-stratified five-fold cross-validation, keeping all phases of each case in the same fold; analysed per-case errors and identified an association between lesion volume and segmentation performance.
  • Implemented reproducible cluster training with GitLab CI, SLURM and Singularity, versioned configurations and experiment tracking.
PyTorchMONAI3D segmentationCross-validation designEvaluation under class imbalancePythonSLURMSingularityDockerGitLab CIMLflowTensorBoard

Research Assistant, Molecular Immunology

2023 — present
I.I. Mechnikov Research Institute of Vaccines and Sera · Prof. O.A. Svitich, MD
  • First author of a conference abstract on hormonal modulation of immune gene expression in HIV-1 infection. Performed RT-qPCR experiments and quantitative analysis contributing to three co-authored peer-reviewed publications.
  • Quantified CCR5/CCR8 and TLR2/4/9 gene expression by RT-qPCR in PBMCs from multiple donors across three HIV-1 subtypes (A6, B, G) and varying hormone concentrations; analysed differences across experimental conditions and donor-to-donor variation.
  • First author of conference abstracts on innate immune gene expression in oral mucosal repair and in a bacteriophage-treated Pseudomonas aeruginosa wound-infection model.
RNA extractioncDNA synthesisRT-qPCRGel electrophoresisIn vivo infection modelsDifferential expressionNon-parametric inferenceDonor variability analysisSmall-cohort designGraphPad PRISMpandasNumPySciPy

Senior Laboratory Technician

2020 — 2023
Functional Neurochemistry, P.K. Anokhin Research Institute of Normal Physiology

Apoptosis-regulator gene expression related to spatial-memory performance (Morris water maze); owned the RT-qPCR workflow end to end.

RT-qPCRRNA extractionGraphPad PRISM

Full methods and detail in the CV.

Peer-reviewed publications

International Journal of Molecular Sciences · 27(18), 8161

Nosik M., Bystritskaya E., Ryzhov K., Kostyuchenko E., Kuzina A., Kravtchenko A., Sevostyanihin S., Demenok I., Zverev V., Svitich O.

Contribution: RNA extraction, cDNA synthesis, RT-qPCR and quantitative analysis.

Viruses · 17(11), 1512

Nosik M., Ryzhov K., Berezhnaya E., Bystritskaya E., Lobach O., Kiseleva I., Kostyuchenko E., Kuzina A., Meremianina E., Kireev D., Svitich O.

Contribution: RNA extraction, cDNA synthesis, RT-qPCR and quantitative analysis.

Bulletin of Experimental Biology and Medicine · 179(4), 480–484

Nosik M.N., Bystritskaya E.P., Ryzhov K.A., Berezhnaya E.V., Lobach O.A., Kiseleva I.A., Kireev D.E., Kuzina A.V., Kostyuchenko E.P., Vasilieva V.E., Zimina A.A., Svitich O.A.

Contribution: RNA extraction, cDNA synthesis, RT-qPCR and quantitative analysis.

Selected presentations

Effect of phage therapy on the expression profile of innate immunity factors in an in vivo Pseudomonas aeruginosa wound infection model
New Approaches in Microbiology, Virology, Immunology and Epidemiology
2026
Oral · first author
Effect of estradiol and progesterone on CCR5/CCR8 coreceptor gene expression in HIV-1 subtype G infection
Lomonosov International Scientific Conference, Fundamental Medicine
2024
1st place, oral
The role of innate immunity gene expression in oral mucosal repair after vestibuloplasty
Medical Spring International Youth Scientific Forum
2025
2nd place, oral
Influence of sex hormones on Toll-like receptor expression in cells infected with HIV-1 subtype G
Lomonosov International Scientific Conference, Experimental Research
2025
Poster · co-author

Posters at the XLVI Scientific Session “Systemic Organisation of Physiological Functions” (2022) and “Current Issues in Developmental Biology” (2021). Ten or more contributions in total, 2021–2026.

Applied ML projects

plaint.com

2025
Problem
Adverse drug reactions are described in free-text patient narratives rather than structured reports.
Approach
LDA/NMF topic modelling, transformer classification and rule-based extraction over 800+ reviews.
Contribution
Built the frontend and backend end to end, integrated the ML/NLP layer into the service and tested the model myself. Winning team, BIOMEDTECH.
RoBERTaPharmBERTscikit-learnFastAPIPython

42.doc

2025
Problem
Matching patients to clinicians requires checkable recommendations, including soft criteria that only appear in patient reviews.
Approach
Review-level RAG: enriched review chunks in pgvector, retrieval over structurally filtered candidates, scores aggregated per clinician with evidence snippets.
Contribution
Built the retrieval pipeline: indexing, semantic ranker, LLM pre-consultation brief; migrated the stack to Qwen. Pitched the project.
RAGpgvectorPostgreSQL

Oncomatrix

2026
Problem
Oncology guidelines change over time, so an answer is only valid against the version in force at the clinical event.
Approach
Temporal retrieval that resolves questions against the date-appropriate guideline version.
Contribution
Built the backend pipeline: chat API with streamed responses and session storage, returning answers with citations from the clinical guidelines, integrated with the frontend.
RAGPostgreSQLSQL

Imaging coursework

2025
Problem
Pathology detection on panoramic dental radiographs and three-class classification of breast ultrasound.
Approach
Object detection for the radiographs; transfer learning for the ultrasound classifier.
Contribution
Trained and evaluated both models: mAP@0.5 0.761 for detection; accuracy 0.87, macro ROC-AUC 0.95 for classification.
YOLOv8PyTorchtorchvisionOpenCVCNNsTransfer learningObject detection

Awards & funding

Scholarship of the Government of the Russian Federation
Granted by federal order under a national quota of 4,500 student awards per year
2024 — 2026
Prize Winner, “I am a Professional” All-Russian Student Olympiad
Preventive Medicine track, two consecutive seasons. In 2024/25, 3,838 medals across 185,610 participants (top 2%)
2024 — 2026
1st place, best oral presentation — Lomonosov International Scientific Conference
Fundamental Medicine. Also 2nd place oral at Medical Spring 2024 and 2025, and 2nd place at the VI Scientific Career Centre Conference, 2022
2024
Winning team, IPHARMA case — BIOMEDTECH championship
Skolkovo × Moscow State University, against 15 teams and 64 participants
2025

Education

I.M. Sechenov First Moscow State Medical University

2020 — 2026
Specialist Degree in Medical Biochemistry — GPA 5.00/5.00 (highest attainable)

Six-year integrated programme; the Russian Specialist Diploma is a single-tier qualification benchmarked at integrated Master’s / MSc level (EQF 7). Institute of Biodesign and Complex Systems Modeling.

School 21 × Sechenov University Joint Campus

2024 — 2025
Artificial Intelligence in Medicine — peer-to-peer engineering programme

Admitted through a competitive selection intensive (3:1); algorithms, systems and relational databases in Bash, SQL/PostgreSQL and Python, followed by a deep learning specialisation in PyTorch.

BashSQLPostgreSQLGitLinuxPythonPyTorch

Sechenov University — Professional Retraining

2023 — 2026
Medical Data Analyst · Translator/Interpreter in Professional Communication (English)